Early calpain-mediated proteolysis following AMPA receptor activation compromises neuronal survival in cultured hippocampal neurons

Autor:	Arsélio P. Carvalho, Ben A. Bahr, António F. Ambrósio, Maria João Verdasca, Ermelindo C. Leal, Inês M. Araújo, Caetana M. Carvalho
Rok vydání:	2004
Předmět:	Neurotoxicity Glutamate receptor Kainate receptor Calpain AMPA receptor Biology medicine.disease Biochemistry Neuroprotection Cell biology Cellular and Molecular Neuroscience chemistry.chemical_compound chemistry medicine biology.protein Cyclothiazide NBQX medicine.drug
Zdroj:	Journal of Neurochemistry. 91:1322-1331
ISSN:	0022-3042
Popis:	In this work, we investigated the involvement of calpains in the neurotoxicity induced by short-term exposure to kainate (KA) in non-desensitizing conditions of AMPA receptor activation (cyclothiazide present, CTZ), in cultured rat hippocampal neurons. The calpain inhibitor MDL28170 had a protective effect in cultures treated with KA plus CTZ (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2eef7c2a755a6ea28fcea66f9203a120 https://doi.org/10.1111/j.1471-4159.2004.02811.x Zobrazit plný text záznamu Plný text