Tratamiento con levotiroxina e imatinib
| Autor: | Ramón Albero Gamboa, Jesús Playán Usón, Patricia de Diego Garcia, Pablo Trincado Aznar |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
endocrine system
Pediatrics medicine.medical_specialty endocrine system diseases business.industry Endocrinology Diabetes and Metabolism Levothyroxine Myeloid leukemia Imatinib Subtotal thyroidectomy Imatinib therapy Endocrinology hemic and lymphatic diseases Medicine In patient Thyroid function business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Endocrinología y Nutrición. 55:304-307 |
| ISSN: | 1575-0922 |
| Popis: | Levothyroxine requirements in patients with hypothyroidism are usually stable. Consequently, thyroid function is usually monitored once or twice yearly. Occasionally, the dose of levothyroxine can be changed by pharmacological reactions. We report the case of a 59-year-old woman who was under levothyroxine therapy for hypothyroidism secondary to subtotal thyroidectomy, with clinical and biochemical euthyroidism, who required an increased dose of levothyroxine after starting imatinib therapy. The patient was diagnosed with chronic myeloid leukemia and imatinib therapy was started. Subsequently, we observed clinical and biochemical hypothyroidism, requiring an increase in levothyroxine dose. Some cases of hypothyroidism after initiation of imatinib therapy in patients with levothyroxine replacement therapy have recently been published. Our case provides further evidence of a reaction between the two drugs. Therefore, we discuss the most likely physiopathological mechanisms contributing to imatinib-induced hypothyroidism in patients under levothyroxine replacement therapy. |
| Databáze: | OpenAIRE |
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