Cytotoxicity and Induction of G1 Phase Cell Cycle Arrest in human acute promyelocytic leukemia HL60 cells by indole alkaloids isolated from Dialium corbisieri seeds

Autor: Dradre Atakuru Paulin, Takuya Koseki, Narandulam Usukhbayar, Ken-ichi Kimura, Yoshihito Shiono
Rok vydání: 2023
Předmět:
Zdroj: Bioscience, Biotechnology, and Biochemistry.
ISSN: 1347-6947
Popis: The phytochemical investigation of Dialium corbisieri seeds led to the isolation of five monoterpenoid indole alkaloids along with a phytoserotonin, 1-6 and among the known compounds, the spectroscopic data of (5S)-methoxy-akuammiline (1) was reported for the first time. The structures were elucidated based on NMR spectroscopic techniques such as UV, IR, HRESITOFMS, and ECD spectrum calculations. The isolated compounds were evaluated for their cytotoxicity and cell progression in the human acute promyelocytic leukemia HL60 cell line.
Databáze: OpenAIRE