| Autor: |
Stephanie J. Fuller, K. Beyreuther, G. Simms, C. L. Masters, G. König, J. Beer, Thomas Dyrks, Andreas Weidemann, D. Bunke, J. M. Salbaum, G. Multhaup, B. Rumble, R. Martins, C. Hilbich, Peter Fischer, Ursula Mönning |
| Rok vydání: |
1988 |
| Předmět: |
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| Zdroj: |
Genetics and Alzheimer’s Disease ISBN: 9783642736490 |
| Popis: |
Alzheimer’s disease affects 1% of the population of the Western world and 100% of aged individuals with Down’s syndrome. It is characterized by neuronal dysfunction and depositions of. amyloid A4 protein (β-protein) in the form of intracellular neurofibrillary tangles, extracellular plaques and cerebrovascular amyloid. Amyloid A4 is a self-aggregating protein that consists of 42–43 residues. “Reverse genetics” based on the sequence of amyloid A4 protein has indicated that the amyloid protein is encoded as part of a larger protein by a gene on chromosome 21. Recent cloning studies have indicated that the amyloid precursor gene encodes at least three alternatively spliced products. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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