Effect of cytomegalovirus infection and leukocyte immunoglobulin like receptor B1 polymorphisms on receptor expression in peripheral blood mononuclear cells
| Autor: | Adriana Monsiváis-Urenda, Sandra Cadena-Mota, Daniel E. Noyola, Mariana Salgado-Bustamante, Sofía Bernal-Silva, Saray Aranda-Romo, César Monjarás-Ávila |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Receptor expression Immunology Haplotype Congenital cytomegalovirus infection Leukocyte Immunoglobulin-like Receptor B1 Biology medicine.disease Microbiology Peripheral blood mononuclear cell LILRB1 03 medical and health sciences 030104 developmental biology Virology medicine Cytomegalovirus Positive Gene |
| Zdroj: | Microbiology and Immunology. 62:755-762 |
| ISSN: | 0385-5600 |
| DOI: | 10.1111/1348-0421.12661 |
| Popis: | Leukocyte immunoglobulin like receptor B1 (LILRB1) plays a significant role in a number of infectious, autoimmune, cardiovascular, and oncologic disorders. LILRB1 expression varies between individuals and may be associated with polymorphisms on the regulatory region of the LILRB1 gene, as well as to previous cytomegalovirus infection. In this study, the contribution of these two factors to LILRB1 expression in peripheral blood mononuclear cells of healthy young adults was analyzed. LILRB1 expression in NK cells, T cells, B cells and monocytes was significantly stronger in individuals who had had cytomegalovirus infection than in those who had not (P |
| Databáze: | OpenAIRE |
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