A 3-year review on the profile of multidrug-resistant Gram-negative in a tertiary teaching hospital in Malaysia
| Autor: | M. Zeehaida, H. Habsah, A.R. Zaidah, Zakuan Zainy Deris, I. Nabilah, H. Siti Asma |
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| Rok vydání: | 2011 |
| Předmět: |
Imipenem
biology business.industry Sulbactam biochemical phenomena metabolism and nutrition Acinetobacter bacterial infections and mycoses biology.organism_classification Meropenem Microbiology Cefoperazone Amikacin Piperacillin/tazobactam polycyclic compounds medicine Netilmicin business medicine.drug |
| Zdroj: | Science and Technology Against Microbial Pathogens. |
| DOI: | 10.1142/9789814354868_0052 |
| Popis: | The objective of this study is to describe the profile of multidrug-resistant (MDR) Gram-negative bacteria in a tertiary teaching hospital at North-Eastern State, Malaysia over a 3-year period (2007-2009). The organisms were identified by conventional method or/and API E or/and API NE. The antimicrobial sensitivity was determined by modified Kirby Bauer method and the sensitivity breakpoints were interpreted according to the Clinical Laboratory Standard Institute. A total of 6978 Gram negative were isolated during that period. 840 (12%) were resistant to 3rd and 4th generation cephalosporin, ciprofloxacin and piperacillin tazobactam. They were Acinetobacter spp. (69%), Klebsiella pneumoniae (14 %) and Pseudomonas aeruginosa (6%). Other organisms found to be resistant were Enterobacter spp (2%), Escherichia coli (2%), Klebsiella spp (3%) and Stenotrophomonas maltophilia (1%). Most of the MDR Gram-negative bacteria were from tracheal aspirates (35%), wound specimens (21%), blood (16%) and urine (13%). They were mostly from intensive care unit (38%) and hospitalized patient (59%). The percentage of organisms sensitive to other antibiotics were to amikacin (42%), gentamicin (14.8%), netilmicin (49.5%), cefoperazone/sulbactam (74.8%), imipenem (25.7%) and meropenem (24.6%) In conclusion, MDR Gram-negative bacteria were high in hospitalized patients, especially from surgical based department. They were mostly isolated from tracheal aspirates and wounds. Cefoperazone/sulbactam and amikacin exhibit the highest percentage of susceptibility. |
| Databáze: | OpenAIRE |
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