Flow trifluoromethylation of carbonyl compounds by Ruppert–Prakash reagent and its application for pharmaceuticals, efavirenz and HSD-016
| Autor: | Norio Shibata, Yoshimasa Yasuda, Satoshi Okusu, Kazuki Hirano, Etsuko Tokunaga |
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| Rok vydání: | 2016 |
| Předmět: |
General method
Efavirenz 010405 organic chemistry Chemistry Trifluoromethylation General Chemical Engineering Enantioselective synthesis General Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Flow system Drug synthesis Reagent Organic chemistry |
| Zdroj: | RSC Advances. 6:82716-82720 |
| ISSN: | 2046-2069 |
| Popis: | The Ruppert–Prakash reagent is the most powerful and well-documented reagent for trifluoromethylation. Despite its versatility, no general method exists for its use in a flow system. Here we report the first flow trifluoromethylation of carbonyl compounds and its utility for drug synthesis of efavirenz and HSD-016, including preliminary results of enantioselective variants. |
| Databáze: | OpenAIRE |
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