THE DISTURBANCE OF OXIDATION-REDUCTION HOMEOSTASIS IN THE HEART MITOCHONDRIA OF DIABETIC RAT WITH ESTROGEN DEFICIENCY

Autor:	Tetiana Kiprich, Olha Ivanova, Oleksii Borikov, Nataliia Gorbenko, K. V. Taran
Rok vydání:	2015
Předmět:	medicine.medical_specialty Disturbance (geology) medicine.drug_class Diabetic rat Chemistry Endocrinology Diabetes and Metabolism Oxidation reduction Mitochondrion Pathology and Forensic Medicine Endocrinology Estrogen Internal medicine medicine Homeostasis
Zdroj:	Problems of Endocrine Pathology. 53:101-106
ISSN:	2518-1432 2227-4782
Popis:	It was investigated the role of estrogen deficiency, type 2 diabetes and their combination in oxidation-reduction homeostasis of the heart mitochondria in experimental rats. It was established that estrogen deficiency and type 2 diabetes leads to oxidative stress in the mitochondria of cardiomyocytes increasing the reactive oxygen species production and reducing the activity of antioxidant enzymes — superoxide dismutase and glutathione, wherein the diabetic condition inhibits the mitochondrial antioxidant system of the heart more than estrogen deficiency. The combination of type 2 diabetes with estrogen deficiency causes additive stimulatory effect on reactive oxygen species production, however, does not increase the negative effects of diabetes on the antioxidant defense system in the heart mitochondria.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2ec24e6d0c42964f09efa5a8f7fe7735 https://doi.org/10.21856/j-pep.2015.3.13 Zobrazit plný text záznamu