Effect of the 5‐HT2A/2C Receptor Agonist DOI on Female Rat Sexual Behavior
| Autor: | F. Giuliano, Jacque Bernabé, Laurent Alexandre, Pierre Denys, Anne-Sophie Rössler |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Agonist
medicine.medical_specialty Animal sexual behaviour Lordosis medicine.drug_class Urology Endocrinology Diabetes and Metabolism Proceptive phase medicine.disease Psychiatry and Mental health Subcutaneous injection chemistry.chemical_compound Endocrinology Reproductive Medicine chemistry Internal medicine Estradiol benzoate medicine Mating Psychology Receptor |
| Zdroj: | The Journal of Sexual Medicine. 3:432-441 |
| ISSN: | 1743-6095 |
| DOI: | 10.1111/j.1743-6109.2006.00240.x |
| Popis: | Introduction Female rats display a repertoire of behaviors during a sexual encounter with a male, including sexually receptive (the lordosis response) and proceptive (darts and hops, and ear wigglings) behaviors. Aim We investigated the effects of subcutaneous injection of the 5‐HT 2A/2C receptor agonist (2,5‐dimethoxy‐4‐idophenyl)‐2‐aminopropane hydrochloride (DOI) on sexual behaviors of ovariectomized female rat hormonally supplemented with estradiol benzoate (10 µg) and progesterone (250 µg). Methods Both female and male sexual behaviors were observed for 10 minutes (pretest). Then females were injected with the treatment and after a 10‐minute delay replaced with the same male for a 30‐minute mating test (posttreatment period). Results DOI (0.5 and 1 mg/kg) significantly increased the number of darts and hops/mounts. In contrast, no significant differences in ear wigglings/mounts were observed. In addition, DOI failed to modify sexual receptivity. Conclusion These data suggest that 5‐HT 2A/2C receptors are important in the regulation of female proceptivity. Rossler A‐S, Bernabe J, Denys P, Alexandre L, and Giuliano F. Effect of the 5‐HT 2A/2C receptor agonist DOI on female rat sexual behavior.J Sex Med 2006;3:432–441. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text