Propofol-sparing effect of different concentrations of dexmedetomidine
| Autor: | Bo Xu, Zu-Rong Hu, Ming Xiong, Jing He, Dennis Grech, Zhao Xin Zheng, Xingan Zhang, Uchenna Madubuko |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.drug_class
business.industry Sedation Sedation scale 030208 emergency & critical care medicine General Medicine Hypnotic 03 medical and health sciences 0302 clinical medicine Anesthesiology and Pain Medicine 030202 anesthesiology Pharmacodynamics Anesthesia Effect site Female patient medicine Dexmedetomidine medicine.symptom Propofol business medicine.drug |
| Zdroj: | Der Anaesthesist. 68:15-21 |
| ISSN: | 1432-055X 0003-2417 |
| DOI: | 10.1007/s00101-018-0506-6 |
| Popis: | The pharmacodynamics of propofol are closely linked to gender. Dexmedetomidine can decrease propofol needs during propofol anesthesia. The aim of this study was to compare the gender differences on the calculated effect site median effective concentration (EC50) of propofol for loss of consciousness (LOC) after pretreatment with different concentrations of dexmedetomidine. In this study 60 male and 60 female patients were randomly allocated to receive dexmedetomidine at target plasma concentrations of 0.0 ng/ml (0.0 group), 0.4 ng/ml (0.4 group), 0.6 ng/ml (0.6 group) and 0.8 ng/ml (0.8 group). Propofol was administered after dexmedetomidine had been intravenously infused for 15 min. The propofol infusion was targeted to provide an initial effect-site concentration of 1.0 μg/ml, followed by increments by 0.2 μg/ml when the effect-site concentration and target concentration of propofol were in equilibrium until LOC was established, where LOC was defined by the observer’s assessment of alertness/sedation scale (OAA/S) score |
| Databáze: | OpenAIRE |
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