Janus Face of the Steric Effect in a Lewis Acid Catalyst with Size-Exclusion Design: Steric Repulsion and Steric Attraction in the Catalytic Exo-Selective Diels–Alder Reaction
| Autor: | Mária Bakos, Dániel Fegyverneki, Zoltán Dobi, Israel Fernández, Ádám Gyömöre, Tibor Soós |
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| Rok vydání: | 2018 |
| Předmět: |
Steric effects
010405 organic chemistry Renewable Energy Sustainability and the Environment General Chemical Engineering Size-exclusion chromatography General Chemistry Borane 010402 general chemistry 01 natural sciences Attraction 0104 chemical sciences Catalysis Lewis acid catalysis chemistry.chemical_compound chemistry Computational chemistry Environmental Chemistry Janus Diels–Alder reaction |
| Zdroj: | ACS Sustainable Chemistry & Engineering. 6:10869-10875 |
| ISSN: | 2168-0485 |
| Popis: | An exo-selective catalytic Diels–Alder reaction was developed using a Lewis acid catalyst with size-exclusion structural design. Exploiting the steric effect, especially the steric attraction, the Lewis acid catalyst was able to reroute the reaction along a higher-energy pathway. The experimental findings were also supported by theoretical calculations. This catalyst development allows an easy and practical access to highly complex and pharmaceutically relevant compounds. |
| Databáze: | OpenAIRE |
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