Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein

Autor:	Dayong Zhai, Robert C. Liddington, Chaofang Jin, Boguslaw Stec, Mika Aoyagi, Alexander E. Aleshin, John C. Reed
Rok vydání:	2006
Předmět:	Viral protein Bcl-2 family Virulence Plasma protein binding Biology medicine.disease_cause Biochemistry Molecular biology Virus chemistry.chemical_compound Protein structure chemistry medicine Vaccinia Molecular Biology Peptide sequence
Zdroj:	Protein Science. 16:118-124
ISSN:	1469-896X 0961-8368
DOI:	10.1110/ps.062454707
Popis:	Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses.
Databáze:	OpenAIRE
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