PURITY DETERMINATION OF PEROXISOMICINE A1 BY HPLC WITH A DIODE ARRAY DETECTOR

Autor:	Alfredo Piñeyro López, Ma. de la Luz Salazar, Noemí Waksman de Torres, Pedro Luis López de Alba
Rok vydání:	2002
Předmět:	Chromatography Chemistry Clinical Biochemistry Analytical chemistry Pharmaceutical Science Reversed-phase chromatography Biochemistry High-performance liquid chromatography Analytical Chemistry chemistry.chemical_compound Chromatography detector Impurity Standard addition Calibration Derivatization Sensitivity (electronics)
Zdroj:	Journal of Liquid Chromatography & Related Technologies. 25:1747-1760
ISSN:	1520-572X 1082-6076
DOI:	10.1081/jlc-120005870
Popis:	A simple and reliable method for determination of isoperoximicine in peroxisomicine-contaminated batches was developed. The method consists of mathematical derivatization of zero order chromatograms, plus a standard addition technique required to increase the sensitivity of the method due to the small amounts of impurity present. Combination of both techniques offers a simple generalized methodology for determination of the final quality product, with potential application in the pharmaceutical field.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2e9347d52cc543524d5657464cb5022a https://doi.org/10.1081/jlc-120005870 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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