Membrane potential based accumulation of antioxidants into mitochondria: implications in neurodegenerative diseases

Autor:	Deepali jat Deepali jat
Rok vydání:	2013
Předmět:	Membrane potential chemistry.chemical_compound chemistry Bioenergetics Biophysics Mitochondrial biology Phosphonium Brain mitochondria Mitochondrion
Zdroj:	IOSR Journal of Environmental Science, Toxicology and Food Technology. 3:32-36
ISSN:	2319-2402 2319-2399
DOI:	10.9790/2402-0353236
Popis:	Lipophilic phosphonium cations were used to investigate mitochondrial biology by delivering them in mitochondria in the late 1960s. Since then, these molecules have become useful for exploring mitochondrial bioenergetics and free radical biology. The cations moves rapidly and carry antioxidants to mitochondria the process is entirely based on membrane potential ( ∆Ψ). Here the investigation is carried out to synthesize and delivered antioxidants to brain mitochondria using lipophilic triphenylphosphonium cation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2e92cf596e38d1de642e2a3b9ae540ab https://doi.org/10.9790/2402-0353236 Zobrazit plný text záznamu