Effect of chlorophos (dipterex, trichlorphon) on high-threshold potassium and calcium channels of the neuronal membrane
| Autor: | Yu. V. Bukanova, E. I. Solntseva |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Voltage-dependent calcium channel
Calcium channel Potassium Inorganic chemistry Antagonist chemistry.chemical_element General Medicine Calcium General Biochemistry Genetics and Molecular Biology Potassium channel Calcium-activated potassium channel chemistry Biophysics medicine Diltiazem medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 121:53-56 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf02445706 |
| Popis: | The effect of chlorophos (dipterex, trichlorphon) on high-threshold potassium and calcium currents is studied on isolated snail neurons using the patch-clamp technique. Chlorophos (10–1000 μmol/liter) is found to reversibly lower the peak amplitude of a high-threshold potassium current by 30% on average and exerts two independent effects on a high-threshold calcium current: reversible lowering of the peak amplitude by 35% on average and, in 30% of cases, reversible inhibition of its activation, inactivation, and deactivation. this effect is abolished by adding diltiazem (a calcium channel antagonist) in a concentration of 100 μmol/liter to the medium. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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