Accessing the impact of functional variants on human phenotypes by transcriptome analysis in individuals carrying different rSNP alleles

Autor:	Victor Nedel'ko, Vladimir Berikov, L. O. Bryzgalov, S. N. Postovalov, Tatiana I. Merkulova, Elena E. Korbolina
Rok vydání:	2020
Předmět:	Transcriptome Differentially expressed genes Functional annotation Single-nucleotide polymorphism Computational biology Epigenome Allele 1000 Genomes Project Biology Phenotype
Zdroj:	2020 Cognitive Sciences, Genomics and Bioinformatics (CSGB).
DOI:	10.1109/csgb51356.2020.9214706
Popis:	the problem of functional annotation of regulatory single nucleotide polymorphisms is considered. Previously we have identified 1476 human regulatory SNPs through an integrated epigenome and transcriptome analysis. Here we employed the analysis of differentially expressed genes in order to explore the extensive impact of these regulatory variants on the phenotypic landscape.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2e8886761fb820fb6148eaed52afb588 https://doi.org/10.1109/csgb51356.2020.9214706 Zobrazit plný text záznamu