A mechanism-based pharmacokinetic-enzyme model for cyclophosphamide autoinduction in breast cancer patients
| Autor: | B Bjorkstrand, Mats O. Karlsson, Mohamed Abdel-Rehim, Per Ljungman, Margareta Bielenstein, M Johansson, Ulrika S H Svensson, Moustapha Hassan, Christina Nilsson, H Olsson |
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| Rok vydání: | 1999 |
| Předmět: |
Pharmacology
Oncology Chemotherapy medicine.medical_specialty Cyclophosphamide medicine.medical_treatment 4-Hydroxycyclophosphamide Metabolite Biology medicine.disease Nitrogen mustard chemistry.chemical_compound Breast cancer Endocrinology chemistry Pharmacokinetics Internal medicine Enzyme model medicine Pharmacology (medical) medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology. 48:669-677 |
| ISSN: | 0306-5251 |
| Popis: | Aims This study investigated the pharmacokinetics of cyclophosphamide (CP) and its main metabolite 4-hydroxycyclophosphamide (4-OH-CP) in patients with breast cancer undergoing high dose chemothera ... |
| Databáze: | OpenAIRE |
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