Abstract TP58: Potential Effect Of Antithrombotic Therapy On Outcome Of Cerebral Infarctionin Association With Hypercoagulability , Nationwide Inpatient Sample,2016-2018
| Autor: | Shyamal C Bir, Prabandh Reddy Buchhanolla, Sandeep Kandregula, Vijayakumar Javalkar, Oleg Y Chernyshev, Bharat Guthikonda, Roger E KELLEY |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Stroke. 53 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/str.53.suppl_1.tp58 |
| Popis: | Objective: The identification of hypercoagulability with acute ischemic stroke can impact on management and potential outcome. We sought to determine the potential effect of antithrombotic therapy on outcome in patients with identified hypercoagulability and cerebral infarct in a nationwide data bank of hospital admissions. Method: We assessed data from the Nationwide Inpatient Sample (NIS) from 2016 to 2018. We looked for the potential association of hypercoagulability, including protein C, protein S and antithrombin III deficiency, the diagnostic code for cerebral infarction, the use of various forms of antithrombotic therapy, and outcome in reference to inpatient mortality, average length of stay (LOS), and discharge to either a rehabilitation center (RC) or a skilled nursing facility (SNF). A P value of Results: Among 124,902 patients coded for hypercoagulability, 35.1%, 2.1 %, and 61.4% patients were on anticoagulants, antiplatelets, and without antithrombotic group, respectively. The prevalence of cerebral infarct was significantly lower in the anticoagulant group, OR 0.61, CI-0.57-0.66, P Conclusion: Patients with hypercoagulability in association with cerebral infarct have a better outcome with anticoagulant therapy than either antiplatelet therapy or no antithrombotic therapy. The worse outcome in the antiplatelet group might reflect a higher risk population for which anticoagulant therapy is not felt to be appropriate or safe. |
| Databáze: | OpenAIRE |
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