Serum leptin levels and energy expenditure in normal weight women
| Autor: | J. F. Caro, Norman F. Boyd, Peter B. Jones, R. V. Considine, Lisa J. Martin, W. Su |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pharmacology
medicine.medical_specialty Physiology business.industry Leptin digestive oral and skin physiology Adipose tissue Radioimmunoassay Doubly labeled water General Medicine Carbohydrate Endocrinology Energy expenditure Physiology (medical) Internal medicine medicine Lean body mass business Body mass index |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 76:237-241 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/y98-006 |
| Popis: | To investigate whether circulating leptin levels are associated with energy expenditure in healthy humans, doubly labeled water energy measurements and food intake assessment were carried out in 27 women (mean age, 48.6 years; weight, 61.9 kg; body mass index, 23.2). Energy expenditure was determined over 13 days. Food intake was measured by 7-day food records. Leptin was measured by radioimmunoassay. Leptin level was strongly associated with percentage body fat (r = 0.59; p < 0.001), fat mass (r = 0.60; p < 0.001), and body mass index (r = 0.41; p = 0.03), but no correlation was observed with energy expenditure (r = 0.02; p = 0.93). After controlling for percentage body fat, a positive association of leptin level with energy expenditure of marginal significance (p = 0.06) was observed. There were no significant univariate associations of age, physical activity, lean body mass, height, or dietary variables with leptin level. When controlling for body fat, a significant positive correlation was observed for percent energy from carbohydrate and negative correlations with dietary fat and alcohol intake. These findings confirm previous associations between leptin and body fat content and suggest a relationship between serum leptin and energy expenditure level in healthy humans.Key words: leptin, energy expenditure, body composition, diet. |
| Databáze: | OpenAIRE |
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