Relationship between retinal nerve fiber layer thickness and the duration and severity of parkinson disease
| Autor: | Ja Cristobal, Ma Del Buey, Jesús Ibáñez, Francisco J. Ascaso, L Cabezon, D. Pérez, J Lopez Del Val, B Jimenez Del Rio |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
genetic structures business.industry Disease duration Nerve fiber layer Retinal General Medicine Neurological disorder medicine.disease eye diseases Surgery Ophthalmology chemistry.chemical_compound medicine.anatomical_structure chemistry Disease severity medicine In patient sense organs Inverse correlation business |
| Zdroj: | Acta Ophthalmologica. 90 |
| ISSN: | 1755-375X |
| DOI: | 10.1111/j.1755-3768.2012.t125.x |
| Popis: | Purpose To determine in patients with Parkinson disease (PD) the correlation between peripapillary retinal nerve fiber layer (RNFL) thickness and macular thickness and volume, with the duration and severity of the neurological disorder. Methods 102 eyes corresponding to patients affected by PD were compared with 97 eyes of age-matched controls. In all individuals peripapillary RNFL thickness, macular thickness and volume were measured by optical coherence tomography (OCT). Results We found statistically significant differences in all parameters of peripapillary RNFL thickness between Parkinson patients and controls. In all quadrants RNFL thickness was significantly lower in PD patients (p = 0.017 in temporal RNFL and p 0.05). Furthermore, we found a significant inverse correlation between disease duration (years) and disease severity measured by Unified Parkinson’s Disease Rating Scale and overall peripapillary RNFL thickness (p=0.002 and p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text