Chiral Amine Enantiomeric Excess Determination Using Self-Assembled Octahedral Fe(II)-Imine Complexes

Autor:	Lee Tran, Justin M. Dragna, Eric V. Anslyn, Vincent M. Lynch, Alexandra M. Gade
Rok vydání:	2015
Předmět:	Pharmacology Circular dichroism Schiff base Chemistry organic chemicals Organic Chemistry Imine Photochemistry Catalysis Analytical Chemistry chemistry.chemical_compound Ultraviolet visible spectroscopy Drug Discovery Polymer chemistry polycyclic compounds heterocyclic compounds Amine gas treating Enantiomeric excess Trifluoromethanesulfonate Spectroscopy Diimine
Zdroj:	Chirality. 27:294-298
ISSN:	0899-0042
DOI:	10.1002/chir.22426
Popis:	A receptor assembly composed of iron(II) triflate and pyridine-2,6-dicarbaldehyde is used to determine the enantiomeric excess of alpha-chiral primary amines using circular dichroism spectroscopy. The alpha chiral amines condense with the dialdehyde to form a diimine, which forms a 2:1 octahedral complex with iron(II). The enantiomeric excess values of unknown concentrations of alpha-chiral amines were determined by constructing calibration curves for each amine and then measuring the ellipticity at 600nm. This improves our previously reported assay for enantiomeric excess determination of chiral primary amines by further increasing the wavelength at which CD is measured and reducing the absolute error of the assay.
Databáze:	OpenAIRE
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