Functional Diversity of Gram-Negative Permeability Barriers Reflected in Antibacterial Activities and Intracellular Accumulation of Antibiotics

Autor:	Inga V. Leus, Justyna Adamiak, Brinda Chandar, Vincent Bonifay, Shibin Zhao, Scott S. Walker, Brian Squadroni, Carl J. Balibar, Nihar Kinarivala, Lisa C. Standke, Henning U. Voss, Derek S. Tan, Valentin V. Rybenkov, Helen I. Zgurskaya
Rok vydání:	2023
Předmět:	Pharmacology Infectious Diseases Pharmacology (medical)
Zdroj:	Antimicrobial Agents and Chemotherapy. 67
ISSN:	1098-6596 0066-4804
Popis:	Gram-negative bacteria are notoriously more resistant to antibiotics than Gram-positive bacteria, primarily due to the presence of the outer membrane and a plethora of active efflux pumps. However, the potency of antibiotics also varies dramatically between different Gram-negative pathogens, suggesting major mechanistic differences in how antibiotics penetrate permeability barriers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2e6ba13b854c0666bc97ac2f8b4f23f1 https://doi.org/10.1128/aac.01377-22 Zobrazit plný text záznamu