Chemotherapy of Brain Metastases from Lung Carcinoma: A Controlled Randomized Study
| Autor: | Hidemitsu Nakagawa, Katsuhito Akagi, Mitsuaki Kanoh, Nobuhiro Kanai, Hiroya Ikeda, Yuzuru Oku, Shoji Bitoh, Hiroshi Hasegawa, Heitaro Mogami, Toru Hayakawa, Norio Arita, Yukitaka Ushio |
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| Rok vydání: | 1991 |
| Předmět: | |
| Zdroj: | Neurosurgery. 28:201-205 |
| ISSN: | 1524-4040 0148-396X |
| DOI: | 10.1227/00006123-199102000-00005 |
| Popis: | A controlled randomized study was carried out to evaluate the effects of chemotherapy in patients with brain metastases from lung carcinoma. One hundred patients were randomly divided into three groups at the time of diagnosis or after surgery for metastases. Group A received radiotherapy alone; Group B received radiotherapy and chloroethylnitrosoureas (methyl-CCNU, 100-120 mg/m2, or ACNU 80-100 mg/m2, every 6-8 weeks), and Group C received radiotherapy and a combination of chloroethylnitrosoureas and tegafur (300 mg/m2. daily). Of the 100 patients, 88 could be evaluated. The reduction rates of the tumors of the patients in whom tumor was not surgically removed or not totally removed were compared. Complete resolution of the tumor was noted in 29, 69, and 63% of the patients in Groups A, B, and C, respectively, Tumor regression of ⩾50% was seen in 36, 69. and 74% of the patients in Groups A, B, and C, respectively. The difference in the response rates of Groups A and C was statistically signficiant (P |
| Databáze: | OpenAIRE |
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