Noninvasive Quantification of Hepatic Steatosis: Relationship Between Obesity Status and Liver Fat Content
| Autor: | T. K. Ponnuswamy, Bruce Green, Sarah McLeay, S. Ramalingam, Glynn A. Morrish, L. Venkatakrishnan, M. Ramanathan, B. Devanand |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Endocrinology Diabetes and Metabolism Fatty liver Computed tomography Overweight medicine.disease Obesity Gastroenterology Transplantation Endocrinology Internal medicine Liver fat Internal Medicine medicine medicine.symptom Steatosis business Body mass index |
| Zdroj: | The Open Obesity Journal. 6:16-24 |
| ISSN: | 1876-8237 |
| DOI: | 10.2174/1876823701406010016 |
| Popis: | The aim of this study was to assess and compare fat content within the liver for normal (body mass index (BMI) < 25 kg/m2), overweight (25-30 kg/m2) and obese (≥ 30 kg/m2) subjects using a noninvasive, non-contrast computed tomography (CT) quantification method. Adult subjects aged 18-60 yrs scheduled to undergo CT examination of the abdominal region were recruited for this study, stratified across BMI categories. Liver volume, fat content, and lean liver volume were determined using CT methods. A total of 100 subjects were recruited, including 30 normal weight, 31 overweight, and 39 obese. Total liver volume increased with BMI, with mean values of 1138 ± 277, 1374 ± 331, and 1766 ± 389 cm3 for the normal, overweight, and obese, respectively (P < 0.001), which was due to an increase in both liver fat content and lean liver volume with BMI. Some obese subjects had no or minimal hepatic fat content. The prevalence of mild fatty liver in this study of 100 subjects was overestimated for all BMI categories using a range of qualitative diagnostic measures, with predicted prevalence of fatty liver in obese subjects ranging from 76.9% for liver-to-spleen ratio ≤ 1.1 to 89.7% for liver attenuation index (liver HU - spleen HU) ≤ 40, compared to 66.7% by quantification of fat content. Results show that total liver volume increases with BMI, however, not all obese subjects display fatty infiltration of the liver. CT quantification of liver fat content may be suitable for accurate diagnosis of hepatic steatosis in clinical practice and assessment of donor livers for transplantation. |
| Databáze: | OpenAIRE |
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