ChemInform Abstract: Nucleophilic Addition of Phenol Derivatives to Methyl 1-Nitrocyclopropanecarboxylates

Autor:	Olga Lifchits, Irina Zakharian, Dino Alberico, André B. Charette
Rok vydání:	2009
Předmět:	chemistry.chemical_compound Nucleophilic addition Nucleophile chemistry Norepinephrine reuptake inhibitor Enantioselective synthesis Phenol General Medicine Enantiomeric excess Ring (chemistry) Medicinal chemistry Cyclopropane
Zdroj:	ChemInform. 40
ISSN:	1522-2667 0931-7597
Popis:	Nucleophilic ring opening of methyl 1-nitrocyclopropanecarboxylates by phenol derivatives in the presence of Cs2CO3 is described. The reaction tolerates a variety of substituents on both the aromatic alcohol and the cyclopropane and affords the products in good yields (53−84%) and with complete preservation of the enantiomeric excess at C-4. The methodology was applied in an enantioselective synthesis of the norepinephrine reuptake inhibitor atomoxetine (Strattera).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2e5cc7a0131fcf089136fd1cf5e6dd30 https://doi.org/10.1002/chin.200902034 Zobrazit plný text záznamu Plný text