Reduction and cyclization in biotransformation of carbonyl compounds by cultured cells ofTaxusspecies

Autor:	Rubén Sánchez-Obregón, Carmen Beatriz Alpízar, Consuelo Sandoval, José M. Méndez, Héctor Barrios
Rok vydání:	2009
Předmět:	biology Stereochemistry Taxus species Plant cell biology.organism_classification Biochemistry Catalysis Taxus brevifolia chemistry.chemical_compound chemistry Biotransformation Cell culture Ethyl acetoacetate Taxus globosa Biotechnology
Zdroj:	Biocatalysis and Biotransformation. 27:36-44
ISSN:	1029-2446 1024-2422
DOI:	10.1080/10242420802475811
Popis:	Cultured plant cells from Taxus brevifolia Nutt and Taxus globosa Schltdl were investigated as biocatalysts using exogenous substrates. Production of highly specific metabolites by these species prompted us to analyse their synthetic potential. Whole cells suspensions have the capacity to chemoselectively reduce ethyl acetoacetate to ethyl 3-hydroxybutyrate chemo- and stereoselectively reduce rac-2-benzoylcyclohexanone to (1R, 2S)- and (1S, 2S)-2-hydroxycyclohexylphenylmethanones, and to cyclize N-phthaloyl-L-glutamine to thalidomide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2e584fa8db30f9b5386a0159255d718e https://doi.org/10.1080/10242420802475811 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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