Modulated charge patterns and noise effect in a twisted DNA model with solvent interaction
| Autor: | Conrad Bertrand Tabi, A. Dang Koko, R. Oumarou Doko, Timoleon Crepin Kofane, H. P. Ekobena Fouda |
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| Rok vydání: | 2016 |
| Předmět: |
Statistics and Probability
Physics Quantitative Biology::Biomolecules Hydrogen bond Molecular models of DNA Torsion (mechanics) Thermal fluctuations Dissipation Condensed Matter Physics 01 natural sciences Instability 010305 fluids & plasmas Solvent Nuclear magnetic resonance Chemical physics 0103 physical sciences Molecule 010306 general physics |
| Zdroj: | Physica A: Statistical Mechanics and its Applications. 442:498-509 |
| ISSN: | 0378-4371 |
| DOI: | 10.1016/j.physa.2015.09.011 |
| Popis: | We modify the Peyrard–Bishop–Holstein model and bring out the influence of the torsion and solvent interactions on charge transport in DNA. Through the linear stability analysis, we detect regions of instability and we compare the results with those of the standard Peyrard–Bishop–Holstein model. There are two regimes where modulated charge patterns can occur: the undertwisted and the overtwisted conformations. Numerical simulations are used to confirm our analytical predictions. Charge patterns are obtained and propagate more easily in an overwinded helix than in an underwinded one. The effects of dissipation and thermal fluctuations are also studied, which confirm the robustness of the obtained modulated patterns. On the one hand, we argue that in the absence of twisting, temperature can lead to the breaking of the hydrogen bonds between bases and prevent charges from propagating. On the other hand, when the molecule is overtwisted, the solvent and the temperature will rather enhance charge spreading patterns with random features. |
| Databáze: | OpenAIRE |
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