Abstract P292: Reversal of Cardiac Remodeling After Surgical Intervention Leads to Distinct Cardiac Function Outcomes
| Autor: | Leonardo Jensen, Amanda Almeida Silva, Nataly Cunha Oliveira, Leandro Eziquiel de Souza, Maria Claudia Costa Irigoyen |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Hypertension. 70 |
| ISSN: | 1524-4563 0194-911X |
| Popis: | Hypertension is the leading cause of cardiovascular diseases Nevertheless diagnosed hypertension can be controlled and monitored with adequate drug regimens. Yet once cardiac hypertrophy is established, a number of patients develop diastolic cardiac dysfunction resulting from cardiac remodeling with fibrosis and cell death. The present study aims to test the hypothesis that animals with aortic stenosis for five weeks can restore cardiac function after the removal of the aortic constriction. Male mice with 10 weeks of age were randomized in three groups Sham , Rem , and Tac . After five weeks of the establishment of cardiac hypertrophy the aortic constriction was removed and the animals were followed for additional five weeks Rem . The positive control group Tac remained with the clip until ten weeks. Echocardiography was performed after 72 hours of the removal of the five weeks stenosis Rem and at the end of ten weeks. We also used cutoff points based on sham group for the ejection fraction EF≥45% and the ratio of E wave per e’ E/e’≤35 . The Rem group was separated into two outcomes according to the presence of dysfunction. Results were expressed as mean ± standard error of the mean SEM. Statistical analyses were performed and p≤0.05 were considered statistically significant. Septum thickness increased after five weeks of stenosis in both Rem 0.812±0.01mm and Tac 0.764±0.02mm groups as compared to sham group 0.675±0.01mm p≤0.05. Left ventricle mass was significantly different in Sham vs Tac 73.98±2.40mg vs 111.79±11.81mg p |
| Databáze: | OpenAIRE |
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