Stereoselective total synthesis of polyketide lactone, (3R,4S,5S,9S)-3,5,9-trihydroxy-4-methylundecanoic acid δ-lactone

Autor:	Peddabuddi Gopal, Jhillu S. Yadav, Gowravaram Sabitha
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Ketone Stereochemistry organic chemicals Organic Chemistry Enantioselective synthesis Total synthesis Catalysis Inorganic Chemistry Polyketide chemistry Stereoselectivity Physical and Theoretical Chemistry δ lactone Lactone
Zdroj:	Tetrahedron: Asymmetry. 20:1493-1499
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2009.06.008
Popis:	The total synthesis of lactone 1 has been described. The convergent asymmetric synthesis relies on the use of an Evans' syn-aldol, chain extension with lithio tert-butyl acetate, and the stereoselective reduction of a ketone as the key reactions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2e260b9716bf03b1972f0483a227b49a https://doi.org/10.1016/j.tetasy.2009.06.008 Zobrazit plný text záznamu Full Text from ScienceDirect