Chronobiological perspectives on myocardial electrophysiological parameters under three types of general anaesthesia in a rat model
| Autor: | Pavol Svorc, Ivana Bacova, Sona Gresova |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Chronobiology
Pentobarbital Physiology business.industry Rat model 030204 cardiovascular system & hematology 03 medical and health sciences Electrophysiology 0302 clinical medicine Physiology (medical) Anesthesia Heart rate Breathing Medicine General anaesthesia PR interval business 030217 neurology & neurosurgery Ecology Evolution Behavior and Systematics medicine.drug |
| Zdroj: | Biological Rhythm Research. 48:343-351 |
| ISSN: | 1744-4179 0929-1016 |
| DOI: | 10.1080/09291016.2016.1263003 |
| Popis: | The specific aim of the present study, with respect to dependence on the light–dark (LD) cycle under in vivo conditions in spontaneously breathing rats was to review initial state in electrophysiological parameters that may predict the development of heart rhythm disorders in pentobarbital (40 mg/kg), ketamine–xylazine (100 + 15 mg/kg) and zoletil (30 mg/kg) anaesthetized animals. The study was performed using female Wistar rats that were adaptated to an LD cycle (12 h:12 h). Heart rate, PQ and QT intervals were evaluated for their dependence on the LD cycle. The longest PQ interval duration is under zoletil anaesthesia in the light period and the longest QT interval duration is under ketamine–xylazine anaesthesia in both light periods. We concluded that the most significant predisposition toward the development of ventricular arrhythmias originating from disorders of impulse production and conduction occurred under zoletil anaesthesia in the light period; those resulting from disorders in the dis... |
| Databáze: | OpenAIRE |
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