PARATHYROI D FUNCTION AND THE PLASMA CITRIC ACID AND CALCIUM RESPONSE TO NEPHRECTOMY1
| Autor: | Smith Freeman, Joseph R. Elliott |
|---|---|
| Rok vydání: | 1956 |
| Předmět: |
Kidney
medicine.medical_specialty medicine.medical_treatment chemistry.chemical_element Metabolism Calcium Nephrectomy chemistry.chemical_compound Endocrinology medicine.anatomical_structure stomatognathic system chemistry Internal medicine medicine Endocrine system Parathyroid gland Kidney surgery Citric acid |
| Zdroj: | Endocrinology. 59:181-189 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-59-2-181 |
| Popis: | THE relation of calcium and citric acid metabolism has been the subject of numerous studies, particularly since Dickens (1) demonstrated that the skeleton is rich in citric acid. However, it has remained a question as to whether or not there is a specific endocrine mechanism relating calcium and citric acid. Evidence presented previously from this laboratory in studies on adult dogs has shown that the hypercitricemia following nephrectomy is largely or entirely abolished if the thyroparathyroid apparatus is removed three weeks prior to nephrectomy (2). Further, that restoration of the serum calcium value of the thyroparathyroidectomized animal to normal by Vitamin D administration, did not restore the plasma citric acid response to nephrectomy. These observations suggest that increased concentration of citric acid in the circulation following nephrectomy depends specifically upon the function of the parathyroid gland. |
| Databáze: | OpenAIRE |
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