Directed lithiation on the quinuclidine ring system: the synthesis of 2,3-difunctionalised quinuclidines

Autor:	Alan P. Chorlton, James Hitchin, David J. Tapolczay, Ian A. O'Neil, Inder Bhamra
Rok vydání:	2008
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Yield (chemistry) Organic Chemistry Drug Discovery Electrophile Ring (chemistry) Biochemistry Combinatorial chemistry Amine oxide Quinuclidine
Zdroj:	Tetrahedron Letters. 49:7416-7418
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2008.10.064
Popis:	Lithiation of 3-methoxymethyl quinuclidine N-oxide occurs regioselectively to generate the 2-lithio 3-methoxymethyl derivative which can be trapped out with non-enolisable electrophiles to give 2,3-disubstituted quinuclidine N-oxide derivatives in good yield.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2e1676d21e50a9114ab49cfa3626a417 https://doi.org/10.1016/j.tetlet.2008.10.064 Zobrazit plný text záznamu Full Text from ScienceDirect