| Autor: | Sergei Nekhai, Willie Turner, Orly Reiner, Yaroslav Voloshin, Nicolas Epie, Tamar Sapir, Tatyana Ammosova, William S. Lane |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
0303 health sciences
Cyclin H biology Microtubule-associated protein RNA polymerase II Jurkat cells Molecular biology 3. Good health Microtubule polymerization Cell biology 03 medical and health sciences 0302 clinical medicine Infectious Diseases Cyclin-dependent kinase Transcription (biology) Virology biology.protein Phosphorylation 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Retrovirology. 2:6 |
| ISSN: | 1742-4690 |
| DOI: | 10.1186/1742-4690-2-6 |
| Popis: | Background HIV-1 Tat activates transcription of HIV-1 viral genes by inducing phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Tat can also disturb cellular metabolism by inhibiting proliferation of antigen-specific T lymphocytes and by inducing cellular apoptosis. Tat-induced apoptosis of T-cells is attributed, in part, to the distortion of microtubules polymerization. LIS1 is a microtubule-associated protein that facilitates microtubule polymerization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|