Investigation of effect of vitamin D receptor, calcium-sensing receptor and β-catenin on cutaneous squamous cell carcinoma
| Autor: | Peyker Temiz, Gulsum Gencoglan, Berrin Tuğrul, Sevinç Söylev |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cutaneous squamous cell carcinoma Chemistry Biochemistry (medical) Clinical Biochemistry Biochemistry Calcitriol receptor 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Catenin Cancer research Calcium-sensing receptor Molecular Biology |
| Zdroj: | Turkish Journal of Biochemistry. 45:91-98 |
| ISSN: | 1303-829X 0250-4685 |
| DOI: | 10.1515/tjb-2019-0434 |
| Popis: | BackgroundCutaneous squamous cell carcinoma (cSCC) is a malignant and invasive tumor which is originated from epidermis with a high incidence among non-melanoma skin cancers. The aim of this study was to determine whether vitamin D receptor (VDR), calcium-sensing receptor (CaSR) and beta catenin (β-catenin) proteins have an effect on cSCC.Materials and methodsVDR, CaSR and β-catenin proteins in tissue samples of cSCC and control group were analyzed by immunohistochemistry (IHC) and Western blotting (WB) method. IHC findings were statistically evaluated.ResultsIHC staining density of VDR and β-catenin were higher in cSCC tissue samples than control. The difference between IHC staining density of VDR and β-catenin in the patient and the control groups were statistically significant (p = 0.021, p = 0.021, respectively), but not for CaSR (p = 0.237). While the VDR and β-catenin staining rates obtained by the IHC method could be supported by WB results, the WB bands for CaSR could not be shown.ConclusionThe findings suggest that VDR and β-catenin may have an effect on the disease. Further research is required to better understand the role of VDR and β-catenin together on cSCC. |
| Databáze: | OpenAIRE |
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