ChemInform Abstract: Synthesis and Anticancer, Antiinflammatory, and Analgesic Activity Evaluation of Some Sulfa Drug and Acridine Derivatives

Autor:	Nidhi Singhal, Ram Raghubir, Rakesh Shukla, Sham M. Sondhi, Monika Johar, Sunanda G. Dastidar
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Sulfathiazole chemistry Sulfa drug Analgesic Condensation Acridine derivatives medicine Organic chemistry General Medicine Methanol medicine.drug
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200036152
Popis:	Various sulfa drugs were condensed with 4-isothiocyanato-4-methyl-2-pentanone at pH∼3–5 by refluxing in methanol to give various substituted mercaptopyrimidines. On condensation with 9-chloro-2-substituted or -unsubstituted acridines, sulfathiazole gave the corresponding condensed products. N-Ethylaminoadenosine reacted with 9-chloroacridine to the coupled product. Condensation of sulfathiazole with 9-isothiocyanato-2,4-substituted or -unsubstituted acridines afforded the corresponding condensed compounds. The structures of all synthesized compounds were confirmed by spectroscopic methods. Anticancer, antiinflammatory, and analgesic activities of all compounds were investigated.
Databáze:	OpenAIRE
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