Etude immunoelectrophoretique des lipoproteines plasmatiques dans un cas de deficience familiale en lecithine-cholesterol acyltransferase
| Autor: | D Chevet, S Salmon, Maryse Ayrault-Jarrier, I Beugler, L. G. Alcindor, R Infante, J Polonovski |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Lecithin cholesterol acyltransferase deficiency
medicine.medical_specialty Very low-density lipoprotein medicine.diagnostic_test biology Chemistry Lipid composition Biochemistry (medical) Clinical Biochemistry Lipoprotein catabolism General Medicine Immunoelectrophoresis medicine.disease Biochemistry Endocrinology Internal medicine Lecithin—cholesterol acyltransferase medicine biology.protein Lipolysis lipids (amino acids peptides and proteins) Lipoprotein |
| Zdroj: | Clinica Chimica Acta. 66:311-318 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/0009-8981(76)90230-8 |
| Popis: | The lipid composition and apopeptide patterns of plasma LDL and VLDL have been studied in a patient with LCAT deficiency, using two-dimensional immunoelectrophoresis. After absorption of a fat meal an elevation of VLDL apopeptides C was observed. Apo-LDL also showed an abnormal relative increase of apo-C. After heparin-induced lipolysis, a shift of apo-C from chylomicra and VLDL to LDL was noticed by the striking increase of apo-C in this last lipoprotein class. In view of the present and previously published results the possible mechanisms involved in lipoprotein catabolism in LCAT deficiency are discussed. |
| Databáze: | OpenAIRE |
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