| Autor: |
De-Yan Hou, Dandamudi V. Rao, Kandula S. R. Sastry, Roger W. Howell, Venkat Narra |
| Rok vydání: |
1991 |
| Předmět: |
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| Zdroj: |
Radiation Research. 128:282 |
| ISSN: |
0033-7587 |
| DOI: |
10.2307/3578051 |
| Popis: |
The problem of determining RBE values for Auger emitters incorporated into proliferating mammalian cells is examined. In general, the reference radiation plays a key role in obtaining experimental RBE values. Using survival of cultured Chinese hamster V79 cells as the experimental model, new data are provided regarding selection of a reference radiation for internal Auger emitters. These data show that γ rays delivered acutely (137 Cs) are more than twice as lethal as γ rays delivered chronically with an exponentially decreasing dose rate (99 m Tc). The results confirm that the reference radiation should be delivered chronically in a manner consistent with the extended exposure received by the cells in the case of incorporated radionuclides. Through a direct comparison of the radiotoxicity of Auger emitters and α emitters, the high RBE values reported for DNA-bound Auger emitters are confirmed. These studies reveal that the DNA binding compound $[{}^{125}{\rm I}]\text{iododeoxyuridine}$ ( ${}^{125}{\rm Id... |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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