Simultaneous and Sequential Protein and Organothiol Interactions with Gold Nanoparticles

Autor:	Xin Yan, Dongmao Zhang, Charles U. Pittman, Kumudu Siriwardana, Keisha B. Walters, Erick S. Vasquez, Karthikeshwar Vangala
Rok vydání:	2013
Předmět:	Colloid General Energy Chromatography biology Colloidal gold Chemistry biology.protein Model protein A protein Physical and Theoretical Chemistry Bovine serum albumin Surfaces Coatings and Films Electronic Optical and Magnetic Materials
Zdroj:	The Journal of Physical Chemistry C. 117:1366-1374
ISSN:	1932-7455 1932-7447
DOI:	10.1021/jp310085u
Popis:	Proteins and organothiols (OTs) are known to have high affinity for gold nanoparticles (AuNPs). Systematic investigation of protein and OT coadsorption onto AuNPs is, however, mostly an unexplored area. Presented here is a comparison of simultaneous and sequential protein and OT interactions with AuNPs in which a protein and an OT are either simultaneously or sequentially added to colloidal AuNPs. Using bovine serum albumin (BSA) as the model protein and eight model organothiols, both the protein and the OT were coadsorbed onto AuNPs in samples formed by sequential or simultaneous addition. AuNP stability against OT-adsorption-induced AuNP aggregation differed significantly among the AuNP/OT and AuNP/BSA/OT mixtures. The stability of AuNPs in the AuNP/BSA/OT mixtures with the same compositions increased from (AuNP/OT)/BSA to AuNP/(BSA/OT) and finally (AuNP/BSA)/OT (where the two components inside the parentheses are mixed first followed by the addition of the third component). Aging the (AuNP/BSA) mixture...
Databáze:	OpenAIRE
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