Structural and metabolic correlates of cell injury in the hypertrophied myocardium during valve replacement
| Autor: | Marcel Seiler, Robert A. Kloner, Karen M. Dalecki-Chipperfield, Kenneth G. Warner, Seok S. Lee, Shukri F. Khuri, Ernest M. Barsamian, Michael D. Butler, Samar N. Assousa, Miguel Josa |
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| Rok vydání: | 1987 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty medicine.diagnostic_test business.industry medicine.medical_treatment valvular heart disease Ischemia medicine.disease Cell morphology medicine.anatomical_structure Valve replacement Ventricular hypertrophy Ventricle Edema Biopsy medicine Surgery medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 93:741-754 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/s0022-5223(19)36356-1 |
| Popis: | To characterize the ultrastructural and metabolic changes occurring in the hypertrophied ventricle during cardiac operations in man, we studied 36 patients with valvular heart disease undergoing valve replacement, during which multiple doses of cold potassium cardioplegic solution were administered (Group I). Each patient had substantial ventricular hypertrophy according to measurements made of left ventricular mass, with a mean of 232.1 ± 19.8 gm/m2 (normal: 92 ± 16 gm/m2). Serial biopsy specimens were obtained from the left ventricular apex at the initiation of bypass, during the cross-clamp interval, and during reperfusion. Each specimen was scored from 0 to 4 according to ischemic changes in nuclear chromatin, mitochondrial swelling, myofibrillar edema, glycogen depletion, and overall cell morphology. Myocardial pH and temperature were measured continuously in the left ventricular free wall. During the cross-clamp period, ischemic injury was evidenced by changes in nuclear chromatin (0.38 ± 0.10 to 1.25 ± 0.21, p |
| Databáze: | OpenAIRE |
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