Isolation, X-ray crystal structure of the new diterpene and identification of others lignans and flavonoids from the fresh needles of Pinus massoniana
| Autor: | Quan-Shu Huang, Ke Xu, Cui-qi Yan, Man-Xi Zhao, Xiao Ke, Zhang-Fei Shi, Li-Tao Liu, Qiao-Xin Tang, Yun-Chuan Xiao, Liang Ye |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
Pinus massoniana biology 010405 organic chemistry Stereochemistry Organic Chemistry X-ray Absolute configuration Pharmaceutical Science General Medicine Crystal structure biology.organism_classification 01 natural sciences 0104 chemical sciences Analytical Chemistry Oxidative damage 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine chemistry Pinaceae Drug Discovery Molecular Medicine Diterpene Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Journal of Asian Natural Products Research. 22:707-715 |
| ISSN: | 1477-2213 1028-6020 |
| DOI: | 10.1080/10286020.2019.1642331 |
| Popis: | Three new compounds, namely massonside C (1), massonianoside F (2), and 3, 8-dimethyl- herbacetin-7-O-β-D-glucopyranoside (3), together with five known compounds (4-8), were isolated from the fresh needles of Pinus massoniana. Their structures were established by 1D, 2D NMR, HRMS and comparison with the literature data. The absolute configuration of 1 was confirmed by a combination of X-ray single crystal analysis. All isolated compounds were evaluated for the protective effect of human umbilical vein endothelial cells against oxidative damage. |
| Databáze: | OpenAIRE |
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