Bridging biomolecules with nanoparticles: surface-enhanced Raman scattering from colon carcinoma and normal tissue

Autor:	I. Domsa, Luisa Andronie, S. Cinta Pinzaru, Onuc Cozar, Simion Astilean
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Biomolecule Nanoparticle Nanotechnology chemistry.chemical_compound symbols.namesake Adsorption medicine.anatomical_structure chemistry Cytoplasm symbols Biophysics medicine General Materials Science Raman spectroscopy Nucleus Spectroscopy DNA Raman scattering
Zdroj:	Journal of Raman Spectroscopy. 39:331-334
ISSN:	1097-4555 0377-0486
DOI:	10.1002/jrs.1907
Popis:	In order to get insight into the chemical heterogeneities of solid tumors, here we report the first surfaceenhanced Raman scattering (SERS) experiment from normal and altered epithelial layer in human colon carcinoma tissues. The Ag colloidal nanoparticles that can be incorporated into the interstitial space in solid tumors or those penetrating into cytoplasm or nucleus of many cells allowed high quality SERS signal. Different tissue structures of tumor and normal colon have characteristic features in SERS spectra. Prominent SERS features of malignant tissue spectra are related to the strong enhancement of the bands preponderantly attributable to DNA or RNA bases. The preliminary studies demonstrate that it is possible to probe Ag colloidal nanoparticles adsorption onto the tissue resulting in a strong molecular signaling with high specificity and rapid acquisition time using visible laser line excitation. Copyright  2008 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2dca57bbfd35805ae42f6d3fd494da78 https://doi.org/10.1002/jrs.1907 Zobrazit plný text záznamu Plný text