SEROLOGY OF THE SYSTEMIC LUPUS ERYTHEMATOSUS IN EGYPTIAN PATIENTS
| Autor: | Azza El-Amir, Mona M. Elamir, Rwan A. Eissa, Alyaa Farid, A. M. K. Nada |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Autoimmune disease
medicine.medical_specialty Systemic lupus erythematosus biology business.industry Autoantibody 010403 inorganic & nuclear chemistry medicine.disease 01 natural sciences Gastroenterology 030218 nuclear medicine & medical imaging 0104 chemical sciences Serology 03 medical and health sciences 0302 clinical medicine Body organs Internal medicine biology.protein Medicine In patient Antibody skin and connective tissue diseases business |
| Zdroj: | Journal of the Egyptian Society of Parasitology. 49:401-404 |
| ISSN: | 2090-2549 |
| DOI: | 10.21608/jesp.2019.68159 |
| Popis: | Systemic lupus erythematosus (SLE) is a prototypic multisystem autoimmune disease with a vast spectrum of clinical presentations including almost all body organs and tissues. The incidence of lupus has tripled in the last 40 years, mainly due to the improved diagnosis. For more than 60 years the presence of autoantibodies in patients with SLE has been known. A great effort is being made for understanding the diagnostic, pathogenic and prognostic meaning of these autoantibodies. The study demonstrated the significance of autoantibodies test in Egyptian SLE patients. The results showed that 93.3% of patients have positive ANA test, 90% have positive anti-dsDNA. Anti-Sm antibodies were in 40% and 49.3% of patients have positive anti-nucleosome antibody test. Also, 30.6% of patients deve-loped a positive anti-histone test & 26% have positive anti-ribosomal test. Anti-phospholipids antibodies were found in 44.6% of patients. Levels of C3 & C4 (0.552±0.43 & 0.125±0.12, respectively) were lower than that of control group (1.2±0.35 & 0.42±0.54 for C3 & C4, respectively). |
| Databáze: | OpenAIRE |
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