Comparison of two amides as backbone replacement of the phosphodiester linkage in oligodeoxynucleotides

Autor:	Jacques Lebreton, Valérie Fritsch, Romain M. Wolf, Alain De Mesmaeker, Adrian Waldner
Rok vydání:	1994
Předmět:	Chemistry medicine.drug_class Oligonucleotide Stereochemistry Dimer Organic Chemistry RNA Carboxamide Biochemistry Deoxyribonucleotide chemistry.chemical_compound Amide Drug Discovery Phosphodiester bond medicine DNA
Zdroj:	Tetrahedron Letters. 35:5225-5228
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)77069-9
Popis:	The two isomeric amide modifications 1 and 2 show similar effects on the melting temperature of RNA/DNA duplexes, when they replace the natural phosphodiester linkage in the DNA strand. The synthesis of the amide dimer 1 is presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2dc186eb4b284186a983dba3374db998 https://doi.org/10.1016/s0040-4039(00)77069-9 Zobrazit plný text záznamu