THE CLINICAL IMPORTANCE OF BIOCHEMICAL BONE MARKERS IN PATIENTS WITH ALCOHOLIC AND VIRAL LIVER CIRRHOSIS / KLINIČKI ZNAČAJ BIOHEMIJSKIH KOŠTANIH MARKERA KOD PACIJENATA SA ALKOHOLNOM I VIRUSNOM CIROZOM JETRE
| Autor: | Jelena Vasic, Dragana Mijac, Violeta Culafic-Vojinovic, Milos Stulic, Đorđe M Ćulafić, Marina Nikolić, Duško Mirković, Svetlana Ignjatović, Milan Petakov |
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| Rok vydání: | 2013 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Bone density Clinical Biochemistry Osteoporosis Gastroenterology Metabolic bone disease 03 medical and health sciences 0302 clinical medicine N-terminal telopeptide Internal medicine medicine Femoral neck Osteomalacia biology business.industry Biochemistry (medical) medicine.disease 3. Good health Osteopenia medicine.anatomical_structure Endocrinology 030220 oncology & carcinogenesis Osteocalcin biology.protein 030211 gastroenterology & hepatology business |
| Zdroj: | Journal of Medical Biochemistry. 33:149-155 |
| ISSN: | 1452-8266 1452-8258 |
| DOI: | 10.2478/jomb-2013-0025 |
| Popis: | Summary Background Metabolic bone disease in patients with chronic liver disease is called hepatic osteodystrophy and is primarily a sequel to osteopenia/osteoporosis, and rarely secondary to osteomalacia. The aim of this work was to define the influence of vitamin D3 and parathyroid hormone (PTH) in the pathogenesis of hepatic osteodystrophy, as well as the predictive significance of biochemical bone markers. MethodsThis prospective study included 58 male patients with alcoholic (49) and viral (9) cirrhosis. The concentrations of serum vitamin D3, PTH, osteocalcin and b-carboxy-ter - minal cross-linked telopeptide of type I collagen (b-CTX) were determined. Bone density was measured by dual energy X-ray absorptiometry in the L1-L4 spinal segment and the femoral neck. Results Lower bone mineral density (BMD) was measured in 41 patients (70.7%). There was no significant correlation between PTH and vitamin D3 values and T score in the femoral neck (p=0.51; p=0.063) and lumbar spine (p=0.49; 0.064). Also, no significant correlation was found between the osteocalcin values in lumbar spine BMD (p=0.944) and femoral neck (p=0.161), or with b-CTX values and BMD in the lumbar spine (p=0.347) and femoral neck (p=0.73). Statistically significant difference was confirmed between the stage A osteocalcin (p=0.000) and b- CTX (p=0.008) values in relation to advanced stages B and C. |
| Databáze: | OpenAIRE |
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