Carbamate Protection of AChE Against Inhibition by Agricultural Chemicals
| Autor: | Barry W. Wilson, Ed DePeters, Francisca J. Rusli, John D. Henderson, Michelle Ka Yan Tam |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Carbamate
Health Toxicology and Mutagenesis medicine.medical_treatment Organophosphate General Medicine Toxicology Biochemistry Acetylcholinesterase chemistry.chemical_compound chemistry Malaoxon Pyridostigmine Soman medicine Molecular Medicine Pyridostigmine Bromide Molecular Biology Nerve agent medicine.drug |
| Zdroj: | Journal of Biochemical and Molecular Toxicology. 26:506-509 |
| ISSN: | 1095-6670 |
| DOI: | 10.1002/jbt.21456 |
| Popis: | The carbamate pyridostigmine bromide has been used as a pretreatment to protect individuals from the nerve agent soman. Previous research showed that pyridostigmine significantly protected human muscle acetylcholinesterase in vitro from soman and bovine red blood cell acetylcholinesterase from some organophosphorous pesticides. Research presented here demonstrates that pretreatment with other carbamates also protects acetylcholinesterase from inhibition by the pesticides chlorpyrifos-oxon and diazinon-oxon, but not from malaoxon. |
| Databáze: | OpenAIRE |
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