ChemInform Abstract: Efficient Synthesis of 2,6-Disubstituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic Acid Ethyl Esters

Autor:	Frank Ruebsam, Zhongxiang Sun, Peter S. Dragovich, Benjamin K. Ayida, Yuefen Zhou, Lian-Sheng Li, Nebojsa Stankovic, Thomas M. Bertolini, Douglas E. Murphy, Jingjing Zhao
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Pyridazine chemistry.chemical_compound chemistry Carboxylic acid Organic chemistry General Medicine Alkylation Ethyl ester
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200820147
Popis:	A general procedure is described for the preparation of 6-substituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters (6-substituted-5-hydroxy-3(2H)-pyridazinone-4-carboxylic acid ethyl esters). These compounds are shown to undergo selective alkylation at the 2-position in moderate to good yields (19–77%) to afford 2,6-disubstituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters (2,6-disubstituted-5-hydroxy-3(2H)-pyridazinone-4-carboxylic acid ethyl esters).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2da168f29c5e2b8f18be6162de2fb29a https://doi.org/10.1002/chin.200820147 Zobrazit plný text záznamu Plný text