Treatment of Bowen Disease With Photodynamic Therapy and the Advantages of Sequential Topical Imiquimod
| Autor: | J.M. Ortiz-Salvador, A.M. Victoria-Martínez, L. Martínez-Leboráns, A. Pérez-Ferriols |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Bowen disease 030103 biophysics Bowen's disease medicine.medical_specialty Histology business.industry medicine.medical_treatment Actinic keratosis Retrospective cohort study Imiquimod Photodynamic therapy Dermatology medicine.disease Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Basal cell carcinoma Adverse effect business medicine.drug |
| Zdroj: | Actas Dermo-Sifiliográficas (English Edition). 108:e9-e14 |
| ISSN: | 1578-2190 |
| DOI: | 10.1016/j.adengl.2016.12.005 |
| Popis: | Photodynamic therapy (PDT) has been shown to be useful and effective in the treatment of actinic keratosis, Bowen disease, and basal cell carcinoma. We present a series of 13 Bowen disease lesions treated using PDT. Complete responses were achieved in 11 (84%) of the lesions after 3 months of treatment; at 18 months, complete responses were seen in 9 (70%) of the lesions. Patients who presented a partial response or recurrence were treated with topical 5% imiquimod and achieved complete responses. The lesions that presented partial response or recurrence were the largest lesions, between 3 and 5cm in diameter. PDT in monotherapy or combined sequentially with imiquimod is an excellent and well-tolerated therapeutic option for Bowen disease. The treatment has few adverse effects and shows satisfactory results, particularly in multiple large lesions in areas of difficult surgical reconstruction or in elderly patients with a high surgical risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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