A comparison of oral sulfate solution with sodium picosulfate: magnesium citrate in split doses as bowel preparation for colonoscopy

Autor: Mark Vb Cleveland, Douglas K. Rex, John E. McGowan, Jack A. DiPalma
Rok vydání: 2014
Předmět:
Zdroj: Gastrointestinal Endoscopy. 80:1113-1123
ISSN: 0016-5107
DOI: 10.1016/j.gie.2014.05.329
Popis: Background There are few data comparing U.S. Food and Drug Administration–approved low-volume bowel preparations for colonoscopy. Objective To compare oral sulfate solution (OSS) with sodium picosulfate plus magnesium citrate (SP+MC) for bowel cleansing efficacy. Design Single-blind, randomized, controlled trial. Setting Ten U.S. centers. Patients Outpatients undergoing colonoscopy for routine indications. Interventions Patients were randomized to undergo bowel preparation with OSS or SP+MC. Both preparations were given in split doses. Main Outcome Measurements Cleansing efficacy on a 4-point scale from excellent (4) to poor (1). Results Among 338 randomized patients who took preparation, OSS resulted in a higher rate of successful (excellent or good) preparation (94.7% vs 85.7%; P = .006) and more excellent preparations (54% vs 26%; P Limitations The preparation grading scale has been used in previous studies and has regulatory acceptance but has not been formally validated. Conclusion The U.S. Food and Drug Administration–approved split-dose regimen of OSS provides superior bowel cleansing compared with the approved split-dose regimen of SP+MC. (Clinical trial registration number: NCT01786629.)
Databáze: OpenAIRE
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