| Autor: |
Angeline Rivkin, Chongyuan Luo, Ethan J. Armand, Ecker, Yueling Li, Zizhen Yao, Anna Bartlett, Jacinta Lucero, Bing Ren, Antonio Pinto-Duarte, Eran A. Mukamel, Sebastian Preissl, Nery, Bosiljka Tasic, Hongkui Zeng, Fangming Xie, M. Margarita Behrens, Hanqing Liu, Olivier Poirion |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.1101/2021.10.25.465795 |
| Popis: |
Integrating single-cell transcriptomes and epigenomes across diverse cell types can link genes with the cis-regulatory elements (CREs) that control expression. Gene co-expression across cell types confounds simple correlation-based analysis and results in high false prediction rates. We developed a procedure that controls for co-expression between genes and integrates multiple molecular modalities, and used it to identify >10,000 gene-CRE pairs that contribute to gene expression programs in different cell types in the mouse brain. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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