Association of childhood trauma with fatigue, depression, stress, and inflammation in breast cancer patients undergoing radiotherapy
| Autor: | Jennifer C. Felger, Donna Mister, Tatiana Han, Anna Lee, Mylin A. Torres, Andrew H. Miller |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Longitudinal study business.industry medicine.medical_treatment CTQ tree Perceived Stress Scale Experimental and Cognitive Psychology medicine.disease Surgery Radiation therapy 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Breast cancer Oncology 030220 oncology & carcinogenesis Internal medicine medicine Prospective cohort study business 030217 neurology & neurosurgery Depression (differential diagnoses) Blood sampling |
| Zdroj: | Psycho-Oncology. 25:187-193 |
| ISSN: | 1057-9249 |
| DOI: | 10.1002/pon.3831 |
| Popis: | Background This pilot study examined whether breast cancer patients with childhood trauma exhibit increased fatigue, depression, and stress in association with inflammation as a result of whole breast radiotherapy (RT). Methods Twenty breast cancer patients were enrolled in a prospective, longitudinal study of fatigue, depression, and perceived stress prior to RT, week 6 of RT, and 6 weeks post-RT. Six weeks after RT, subjects completed the childhood trauma questionnaire (CTQ). Patients were also administered the multidimensional fatigue inventory, inventory of depressive symptomatology-self-reported, and perceived stress scale at all three time-points and underwent blood sampling prior to RT for gene expression and inflammatory markers previously associated with childhood trauma and behavioral symptoms in breast cancer patients. Results Eight subjects (40%) had past childhood trauma (CTQ+). Compared to CTQ− patients, CTQ+ patients had significantly higher fatigue, depression, and stress scores before, during, and after RT (p |
| Databáze: | OpenAIRE |
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